1-13 CHONDROCYTE HOMEOSTASIS

Effects of Wnt3A and mechanical load on cartilage chondrocyte homeostasis

INTRODUCTION Articular cartilage functions in withstanding mechanical loads and provides a lubricating surface for frictionless movement of joints. Osteoarthritis, characterised by cartilage degeneration, develops due to the progressive erosion of structural integrity and eventual loss of functional performance. Osteoarthritis is a multi-factorial disorder; two important risk factors are abnorm...

The chondrocyte clock gene Bmal1 controls cartilage homeostasis and integrity.

Osteoarthritis (OA) is the most prevalent and debilitating joint disease, and there are currently no effective disease-modifying treatments available. Multiple risk factors for OA, such as aging, result in progressive damage and loss of articular cartilage. Autonomous circadian clocks have been identified in mouse cartilage, and environmental disruption of circadian rhythms in mice predisposes ...

Cover vol. 13, no. 1, February 2016

ABSTRACTS IN PERSIAN Vol.13, No.1

Please see the full text contains the Pesian abstracts for this volume.

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